亚投彩票

高脂饲料诱导不同实验动物AS模型的差异

YANJIUDONGMAIZHOUYANGYINGHUA(AS)BINGBIANJIXIANGGUANYAOWUDEZUOYONGJIZHISHI,WUFABIKAIDEYIGEWENTIJIUSHIRUHEXUANZESHIYANDONGWU?SHISHISHANG,BINGMEIYOUWANMEIDEMOXING,ZHIYOUGENGSHIHEDEMOXING。ASDONGWUMOXINGBINGBIANTEZHENGJUYOUMINGXIANDEZHONGSHUCHAYI。ZHIYOUCHONGFENPINGGUZHEIXIECHAYI,CAINENGZAISHIYANHOUQILENGJINGYINGDUI。

一、ApoE-/-小鼠

JINGUANApoE-/-XIAOSHUYISHIMUQIANYANJIUASZUICHANGYONGDEZHUANJIYINDONGWUMOXING,DANSHIRUGUODALIANGYONGYUSHIYAN,GUANGDONGWUGOUZHIFEIJIUXUYAOSHUWANYUAN。

DANCHUNDEApoE-/-XIAOSHUZAI3YUELINGSHIJIUHUICHUXIANDONGMAIZHIFANGDUIJI,RUGUOPEIHEGAOZHISILIAO,HUIHENKUAICHUXIANDIANXINGDEZAOQIASBINGBIAN,FEICHANGLIYUYANJIUZHEDUIASBINGBIANDEFASHENG、FAZHANGUOCHENGHEXINGCHENGJIZHIJINXINGYANJIU。

DANSHI,SILIAOZHONGDANGUCHUNDEBILIBUTONGHUIZAOCHENGApoE-/-XIAOSHUBINGBIANBUWEIDEBIANYIXING。ASBINGBIANBUWEIKENENGZAIZHUDONGMAIGONG、XIONGZHUDONGMAI、FUZHUDONGMAIZHIJIANFASHENGBIANHUA,BINGBIANCHENGDUSHANGYEHUIYOUCHAYI。ApoE-/-XIAOSHUCAIYONGGAOZHISILIAOWEISHIHOU,ASBINGBIANTONGCHANGJIAOZHONG,ZHUYAOTIXIANZAIXUEGUANNEIMODANGUCHUNCHENJI,BANKUAIJIAOZHONG,DANSHIHENSHAOJIANDAOBANKUAIPOLIEHOUXUESHUANXINGCHENG。

RUGUOASBINGBIANTAIZHONG,DUIYUYAOWUYANJIULAISHUOSHIBUTAIYOULIDE,KENENGHUIZAOCHENGJIAYINXING。ZONGTILAISHUO,YATOUCAIPIAORENWEIGAOZHISILIAOWEISHIApoE-/-XIAOSHUYOUDAOASGENGSHIHEYONGYUYANJIUJIBINGJIZHI。

二、SD大鼠

DASHUDUIGAOZHIYINSHIBINGBUMINGAN,DANCHUNGAOZHIYINSHIYOUDAOSHIHENNANZAOMOCHENGGONGDE。JINGUANYOUWENXIANBIAOMINGZAISILIAOZHONGJIARUDANSUANNAHEKANGJIAZHUANGXIANYAOWU,KEYICUJINDANGUCHUNXISHOU,DANXIAOGUORENGRANYOUXIAN。

DASHUKENENGZUIZHONGHUIYOUMINGXIANGAOZHIXUEZHENGHEXUEGUANNEIMODANGUCHUNCHENJI,DANSHINANYICHUXIANBANKUAI,YURENLEIASBINGBIANXIANGQUSHENYUAN。BUGUO,ZHEIYEJIESHILEYIGEXIANXIANG,JIDASHUGAOXUEZHIYUQINGBINGBIANDEMAODUN。

三、新西兰兔

TUZIDUIDANGUCHUNXISHOULVKEDA75%-90%,ERQIEDUIXUEZHIDEQINGCHUNENGLIHENRUO。YINCI,ZHIYAOJIYUGAOZHISILIAOWEIYANG,HENKUAIJIUHUIXINGCHENGAS,FEICHANGYOULIYUDUANQINEIYAOWUSHAIXUAN。

GAOZHISILIAOWEISHIDETUZIASBINGBIANTEZHENGSHINEIMOZHIZHICHENJI、ZHONGMODANLIXIANWEIPOHUAI,HENNANDADAOZHOUYANGBANKUAIDECHENGDU,ZHEIYIDIANYURENLEIASCUNZAICHAYI。DANSHIHUANGEJIAODUKAN,TUZIASMOXINGSIHUTEBIESHIYONGYUYANJIUASZAOQIDEXUEGUANNEIMO、ZHONGMOSUNSHANGJIZHI。

CIWAI,YOUYUZHANGQIDEGAOZHIYINSHI,YOUNANYIDAIXIE,TUZIJINGCHANGHUICHUXIANGANSHENGONGNENGSUNHAI。GAOZHISILIAOWEISHI1GEYUESHI,TUZIYIZHUJIANKANGJUJINSHI,TIZHONGJIANQING,SHENZHIKENENGCHUXIANDANGUCHUNZHONGDUERSIWANGDEZHUANGKUANG。

TUZIHAIYOUYIGETEZHENG,JIUSHIDUISHIYANHUANJINGYAOQIUJIAOGAO。GAOZHIYINSHIJIASHANGSHENGHUOHUANJINGBUJIA,TUZIJIYICHUXIANFUXIE,ZHANGQIFUXIEHUIJINYIBUDAOZHITIYEDIUSHI、DIANJIEZHIWENLUAN、SUANJIANPINGHENGSHIDIAO,YEHUIDAOZHIDONGWUSIWANG。

标签:动脉粥样硬化模型高脂饲料 上一篇: 下一篇:
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